Social Neurocognition and the Cerebellum: Correlations Between Reading the Mind in the Eyes Test Scores and Cerebellar Morphometry in Patients with Behavioral Variant Frontotemporal Dementia
Authors: Martín Mazzoglio y Nabar, Rubén Daniel Algieri, Milagros María Muñiz, Emmanuel Leidi Terren, Agustín Daniel Algieri, Soledad Ferrante, Elba Tornese
Summary
Behavioral variant frontotemporal dementia (bvFTD) poses significant challenges for early diagnosis and is characterized by early impairments in social cognition. Recent evidence suggests the involvement of extracortical structures, particularly the cerebellum, in its pathophysiology. In this context, the present study aimed to analyze the correlation between performance on social cognition tasks and cerebellar morphometry in patients with bvFTD, considering its clinical and forensic relevance. Forty-nine patients with bvFTD were evaluated using the Reading the Mind in the Eyes Test and the Faux Pas Test. Clinical severity was assessed with the Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), and Frontotemporal Dementia Rating Scale (FTD-FRS). Structural brain MRI (1.5 T) was performed, including morphometric analysis of the cerebellar vermis and subsequent correlational analyses. A high prevalence of social cognition impairments was observed from the early stages of the disease. The Faux Pas Test demonstrated greater clinical sensitivity. Performance on the Reading the Mind in the Eyes Test showed a strong correlation with volumetric reduction of the posteroinferior cerebellar vermis (r = 0.89; p < 0.01). These findings support the role of the cerebellum, particularly the vermis, in social neurocognition in bvFTD and highlight its potential as an early structural biomarker.
Keywords
Cerebellum, Morphometry, Social cognition, Frontotemporal dementia